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Lexapro is an oral medication that is used for treating depression and generalized anxiety disorder. Chemically, escitalopram is similar to citalopram (Celexa) and both are in the class of drugs called selective serotonin reuptake inhibitors (SSRIs), a class that also includes fluoxetine (Prozac), paroxetine (Paxil) and sertraline (Zoloft). SSRIs work by affecting neurotransmitters in the brain, the chemical messengers that nerves use to communicate with each another. Neurotransmitters are made and released by nerves and then moves to other nearby nerves where they attach to receptors on the nerves. Some neurotransmitters that are released do not bind to receptors in the brain and are taken up by the nerves that produced them. This is what we call as "reuptake." Many experts believe that an imbalance of neurotransmitters is the root cause of depression. Lexapro prevents the reuptake of one neurotransmitter, serotonin, by nerves, an action which results in more serotonin in the brain to attach to receptors. This drug is approved for the treatment of generalized anxiety disorder and depression.Drugs in the SSRI class also have been studied in persons with obsessive compulsive disorders and panic disorders, but this drug is not approved for this purpose.
The usual starting dose of Lexapro is 10 mg once daily in the morning or evening. The dose may be increased to 20 mg once daily after 1 week but the benefit may not be seen until treatment has been given for up to 4 weeks. A daily dose of 20 mg may not be anymore effective than 10 mg daily for treatment of depression and it can be taken with or without food.
All SSRIs, including Lexapro, should not be combined with drugs in the monoamine oxidase (MAO) inhibitor class of antidepressants such as isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Eldepryl) and procarbazine (Matulane). Such combinations may cause confusion, high blood pressure, high fevers, tremor or muscle rigidity, and increased activity.